Price research

The Price Lab is committed to defining the basic mechanisms that regulate transcription by RNA polymerase II. We apply both biochemical, molecular, and global bioinformatics tools to understand how transcription is controlled in the context of chromatin. Most of our current work is focused on human cells and the viruses that infect them.

Learn more about research in the Price Lab on the current projects page.

Recent Publications

Santana JF, Collins GS, Parida M, Luse DS, Price DH (2022) Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB. Nucleic Acids Res. doi: 10.1093/nar/gkac678.

Ball CB, Li M, Parida M, Hu Q, Ince D, Collins GS, Meier JL, and Price DH (2022) Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner mBio doi: 10.1128/mbio.00337-22.

Spector BM, Parida M, Li M, Ball CB, Meier JL, Luse DS, Price DH (2022) Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes Nat Commun. doi: 10.1038/s41467-022-29739-x.

Ball CB, Parida M, Li M, Spector BM, Suarez GA, Meier JL, Price DH (2022) Human Cytomegalovirus Infection Elicits Global Changes in Host Transcription by RNA Polymerases I, II, and III, Viruses, doi: 10.3390/v14040779.

Ball CB, Parida M, Santana JF, Spector BM, Suarez GA, Price DH, Nuclear export restricts Gdown1 to a mitotic function. Nucleic Acids Res. 2022 Jan 20:gkac015. doi: 10.1093/nar/gkac015.

Li M, Hu Q, Collins GS, Parida M, Ball C.B., Price DH, and Meier,JL (2021) Cytomegalovirus Late Transcription Factor Target Sequence Diversity Orchestrates Viral Early to Late Transcription PLoS Pathog. 17(8):e1009796. doi: 10.1371/journal.ppat.1009796.

Luse DS Parida M, Spector BM, Nilson KA, and Price DH (2020) A Unified View of the Sequence and Functional Organization of the Human RNA Polymerase II Promoter, Nucleic Acids Res. 48(14):7767-7785. doi: 10.1093/nar/gkaa531.

Li M, Ball CB, Hu Q, Luse DS, Price DH, and Meier J. (2020) Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II. PLoS Pathog. 2020 Apr 6;16(4):e1008402. doi: 10.1371/journal.ppat.1008402.

Visit Google Scholar for all of Dr. Price's publications.

Events

Biochemistry and Molecular Biology Seminar: Dr. Melissa Jurica promotional image

Biochemistry and Molecular Biology Seminar: Dr. Melissa Jurica

Thursday, September 18, 2025 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public."Exploring intron recognition by U2 snRNP with spliceosome inhibitors"Melissa Jurica, PhDUniversity of California Santa CruzFaculty Host: Lori Wallrath, PhD

College of Pharmacy PSET Seminar Series: Mara Steinkamp, PhD

Tuesday, September 23, 2025 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: Mara Steinkamp, PhDAssistant ProfessorDepartment of PathologyUniversity of New MexicoAlbuquerque, New MexicoAll are welcome to attend. No pre-registration required.

College of Pharmacy PSET Seminar Series: Guohua An, MD, PhD

Tuesday, September 30, 2025 11:30am
College of Pharmacy Building
The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: Guohua An, MD, PhDAssociate ProfessorDepartment of Pharmaceutical Sciences and Experimental TherapeuticsUniversity of IowaIowa City, IAAll are welcome to attend. No pre-registration required.