About the Lab

The Price Lab is committed to defining the basic mechanisms that regulate the elongation phase of transcription by RNA polymerase II. We apply both biochemical, molecular, and global bioinformatics tools to understand how elongation is controlled. Most of our current work is focused on human cells and the viruses that infect them.

Learn more about research in the Price Lab on the current projects page.

Recent Publications 

Price D.H. (2018) Transient Pausing by RNA Polymerase II, PNAS, 115(19):4810-4812. doi: 10.1073/pnas..

Mullen, NJ and Price DH (2017) Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function, PLOS ONE Oct 13;12(10):e0186423. doi: 10.1371/journal.pone.0186423.

Nilson, K.A., Lawson, C.K., Mullen, N.J., Ball, C.B., Spector, B.M., Meier, J.L., Price, D.H. (2017) Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. Nucleic Acids Res. doi.org/10.1093/nar/gkx262.

Brogie, J.E and Price D.H. (2017) Reconstitution of a functional 7SK snRNP. Nucleic Acids Res. doi: 10.1093/nar/gkx262.

Bosque, A., Nilson, K.A., Macedo, A.B., Spivak, A.M., Archin, N., Van Wagoner, R.M., Martins, L.J., Novis, C.L., Szaniawski, M.A., Ireland, C.M., Margolis, D.M, Price, D.H., Planelles, V. (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Reports, 18:1324-1334.

Tan, J.L, Fogley, R.D., Flynn, R.A., Ablain, J., Yang, S., Saint-André, V., Fan, Z.P., Do, B.T.,  Laga A.C., Fujinaga K., Santoriello, C., Greer, C.B., Kim Y.J., Clohessy, J.G., Bothmer, A., Pandell, N., Avagyan, D., Brogie, J.E., van Rooijen, E., Hagedorn, E.J., Shyh-Chang, N., White, R.M., Price, D.H., Pandolfi, P.P., Peterlin, B.M., Zhou, Y., Kim, T.H., Asara, J.M., Chang, H.Y., Young, R.A., and Zon, L.I. (2016) Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Molecular Cell 62:34-46.

Nilson, K.A., Guo, J., Turek, M.E., Brogie, J.E., Delaney, E., Luse, D.S., Price, D.H. (2015) THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.   Mol Cell. 59(4):576-87. 

Gu, J., Babayeva, N.D., Suwa, Y., Baranovskiy, A.G., Price, D.H., and Tahirov, T.H. (2014) Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle 13(11):1788-97

Visit Google Scholar for all of Dr. Price's publications.