About the Lab

The Price Lab is committed to defining the basic mechanisms that regulate the elongation phase of transcription by RNA polymerase II. We apply both biochemical, molecular, and global bioinformatics tools to understand how elongation is controlled. Most of our current work is focused on human cells and the viruses that infect them.

Learn more about research in the Price Lab on the current projects page.

Recent Publications 

Mullen, NJ and Price DH (2017) Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function, PLOS ONE Oct 13;12(10):e0186423. doi: 10.1371/journal.pone.0186423.

Nilson, K.A., Lawson, C.K., Mullen, N.J., Ball, C.B., Spector, B.M., Meier, J.L., Price, D.H. (2017) Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. Nucleic Acids Res. doi.org/10.1093/nar/gkx262.

Brogie, J.E and Price D.H. (2017) Reconstitution of a functional 7SK snRNP. Nucleic Acids Res. doi: 10.1093/nar/gkx262.

Bosque, A., Nilson, K.A., Macedo, A.B., Spivak, A.M., Archin, N., Van Wagoner, R.M., Martins, L.J., Novis, C.L., Szaniawski, M.A., Ireland, C.M., Margolis, D.M, Price, D.H., Planelles, V. (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Reports, 18:1324-1334.

Tan, J.L, Fogley, R.D., Flynn, R.A., Ablain, J., Yang, S., Saint-André, V., Fan, Z.P., Do, B.T.,  Laga A.C., Fujinaga K., Santoriello, C., Greer, C.B., Kim Y.J., Clohessy, J.G., Bothmer, A., Pandell, N., Avagyan, D., Brogie, J.E., van Rooijen, E., Hagedorn, E.J., Shyh-Chang, N., White, R.M., Price, D.H., Pandolfi, P.P., Peterlin, B.M., Zhou, Y., Kim, T.H., Asara, J.M., Chang, H.Y., Young, R.A., and Zon, L.I. (2016) Stress from nucleotide depletion activates the transcriptional regulator HEXIM1 to suppress melanoma. Molecular Cell 62:34-46.

Nilson, K.A., Guo, J., Turek, M.E., Brogie, J.E., Delaney, E., Luse, D.S., Price, D.H. (2015) THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.   Mol Cell. 59(4):576-87. 

Gu, J., Babayeva, N.D., Suwa, Y., Baranovskiy, A.G., Price, D.H., and Tahirov, T.H. (2014) Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle 13(11):1788-97

Guo, J., Turek, M.E., and Price, D.H. (2014) Regulation of RNA polymerase II termination by phosphorylation of Gdown1. J Biol Chem. 289(18):12657-65.

Davis, M.A., Guo, J., Price, D.H., and Luse, D.S. (2014) Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF. J Biol Chem. 289(16):11143-52. 

Liu, P., Xiang, Y., Fujinaga, K., Bartholomeeusen, K., Nilson, K., Price, D.H., and Peterlin, B.M. (2014) Release of P-TEFb from 7SK snRNP activates HEXIM1 transcription. J Biol Chem. 289(14):9918-25.

Fowler. T, Ghatak, P, Price, D.H., Conaway, R., Conaway, J., Chiang, C.M., Bradner J.E., Shilatifard, and A, Roy A.L. (2014) Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells. PLoS One 9:e87003. doi: 10.1371/journal.pone.0087003. 

Guo J and Price D. (2013) RNA polymerase II transcription elongation control. Chem Rev.  113(11):8583-603.  

Guo J, Li T, and Price D. (2013) Runaway transcription. Genome Biol. 19(9):133.  

Duyne, R.V., Guendel, I., Jaworski, E., Sampey, G., Klase, Z., Chen, H., Zeng, C., Kovalskyy, D., Lepene, B., Patanarut, A., Nekhai, S., Price, D.H. and Kashanchi, F. (2013) Effect of mimetic Cdk9 inhibitors on HIV-1 activated transcription. J Mol Biol, 425(4):812-29.

Zhou, Q., Li, T. and Price, D.H. (2012) RNA Polymerase II Elongation Control. Annual Review of Biochemistry, 81:119-43.

Kulak, M.V., Cyr, A.R., Woodfield, G.W., Bogachek, M., Spanheimer, P.M., Li, T., Price, D.H., Domann, F.E. and Weigel, R.J. (2012) Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene, doi: 10.1038/onc.2012.400 [Epub ahead of print].

Fujinaga, K., Barboric, M., Li, Q., Luo, Z., Price, D.H. and Peterlin, B.M. (2012) PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nuc. Acids Res. (Epub PMID: 22821562).

Li, T. and Price, D.H. (2012) Gdown1- mkaing a link between Mediator and RNA polymerase II elongation control. Transcription, 3:1-3.

Nguyen, D., Krueger, B.J., Sedore, S.C., Brogie, J.E., Rogers, J.T., Rajendra, T.K., Saunders, A., Matera, A.G., Lis, J.T., Uguen, P. and Price, D.H. (2012) The Drosophila 7SK snRNP and the essential role of dHEXIM in development. Nuc. Acids Res. (Epub PMID: 22379134).

Cheng, B., Li, T., Rahl, P.B., Adamson, T.E., Loudas, N.B., Gou, J., Varzavand, K., Cooper, J.J., Hu, X., Gnatt, A., Young, R.A. and Price, D.H. (2012) Functional association of Gdown1 with RNA polymerase II poised on human genes. Molecular Cell, 45:38-50.

Peterlin, B.M., Brogie, J.E. and Price, D.H. (2012) 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. WIREs RNA 2012, 3:92-103.

Nilson, K.A. and Price, D.H. (2011) The role of RNA polymerase II elongation control in HIV-1 gene expression, replication, and latency. Genetics Research International Volume 2011, Article ID 726901.

Cojocaru, M., Bouchard, A. Cloutier, P. Cooper, J.J., Varzavand, K. Price D.H. Coulombe B. (2011) Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor b.  J. Biol. Chem. 286:5012-22.

Bartkowiak, B., Liu, P., Phatnani, H.P., Fuda, N.J., Cooper, J.J., Price, D.H., Adelman, K, Lis, J.T., and Greenleaf, A.L. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & Development 24:2303-16.

Price, D.H. (2010) Regulation of RNA polymerase II elongation by c-Myc. Cell. Apr 30;141(3):399-400.

Krueger, B.J., Varzavand, K., Cooper, J.J., and Price, D.H. (2010) The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators incudes a conformational change in 7SK. PLoS ONE 23:e12335.

Tahirov, T.H., Babayeva, N.D., Varzavand, K., Cooper, J.J., Sedore, S.C., and Price, D.H. (2010) Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature, 465:747-751

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