The Price Lab is committed to defining the basic mechanisms that regulate transcription by RNA polymerase II. We apply both biochemical, molecular, and global bioinformatics tools to understand how transcription is controlled in the context of chromatin. Most of our current work is focused on human cells and the viruses that infect them.
Learn more about research in the Price Lab on the current projects page.
Recent Publications
Santana JF, Collins GS, Parida M, Luse DS, Price DH (2022) Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB. Nucleic Acids Res. doi: 10.1093/nar/gkac678.
Ball CB, Li M, Parida M, Hu Q, Ince D, Collins GS, Meier JL, and Price DH (2022) Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner mBio doi: 10.1128/mbio.00337-22.
Spector BM, Parida M, Li M, Ball CB, Meier JL, Luse DS, Price DH (2022) Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes Nat Commun. doi: 10.1038/s41467-022-29739-x.
Ball CB, Parida M, Li M, Spector BM, Suarez GA, Meier JL, Price DH (2022) Human Cytomegalovirus Infection Elicits Global Changes in Host Transcription by RNA Polymerases I, II, and III, Viruses, doi: 10.3390/v14040779.
Ball CB, Parida M, Santana JF, Spector BM, Suarez GA, Price DH, Nuclear export restricts Gdown1 to a mitotic function. Nucleic Acids Res. 2022 Jan 20:gkac015. doi: 10.1093/nar/gkac015.
Li M, Hu Q, Collins GS, Parida M, Ball C.B., Price DH, and Meier,JL (2021) Cytomegalovirus Late Transcription Factor Target Sequence Diversity Orchestrates Viral Early to Late Transcription PLoS Pathog. 17(8):e1009796. doi: 10.1371/journal.ppat.1009796.
Luse DS Parida M, Spector BM, Nilson KA, and Price DH (2020) A Unified View of the Sequence and Functional Organization of the Human RNA Polymerase II Promoter, Nucleic Acids Res. 48(14):7767-7785. doi: 10.1093/nar/gkaa531.
Li M, Ball CB, Hu Q, Luse DS, Price DH, and Meier J. (2020) Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II. PLoS Pathog. 2020 Apr 6;16(4):e1008402. doi: 10.1371/journal.ppat.1008402.
Visit Google Scholar for all of Dr. Price's publications.
