About the Lab

The Price Lab is committed to defining the basic mechanisms that regulate the elongation phase of transcription by RNA polymerase II. We apply both biochemical and molecular tools to understand how elongation is controlled by the positive transcription elongation factor, P-TEFb and how that factor is itself controlled by the 7SK snRNP. We utilize HIV as a model system and one of our long term goals is to develop new anti-HIV therapies.

Learn more about research in the Price Lab on the current projects page.

Recent Publications 

Nilson, K.A., Guo, J., Turek, M.E., Brogie, J.E., Delaney, E., Luse, D.S., Price, D.H. (2015) THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.   Mol Cell. 59(4):576-87. 

Gu, J., Babayeva, N.D., Suwa, Y., Baranovskiy, A.G., Price, D.H., and Tahirov, T.H. (2014) Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle 13(11):1788-97

Guo, J., Turek, M.E., and Price, D.H. (2014) Regulation of RNA polymerase II termination by phosphorylation of Gdown1. J Biol Chem. 289(18):12657-65.

Davis, M.A., Guo, J., Price, D.H., and Luse, D.S. (2014) Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF. J Biol Chem. 289(16):11143-52. 

Liu, P., Xiang, Y., Fujinaga, K., Bartholomeeusen, K., Nilson, K., Price, D.H., and Peterlin, B.M. (2014) Release of P-TEFb from 7SK snRNP activates HEXIM1 transcription. J Biol Chem. 289(14):9918-25.

Fowler. T, Ghatak, P, Price, D.H., Conaway, R., Conaway, J., Chiang, C.M., Bradner J.E., Shilatifard, and A, Roy A.L. (2014) Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells. PLoS One 9:e87003. doi: 10.1371/journal.pone.0087003. 

Guo J and Price D. (2013) RNA polymerase II transcription elongation control. Chem Rev.  113(11):8583-603.  

Guo J, Li T, and Price D. (2013) Runaway transcription. Genome Biol. 19(9):133.  

Duyne, R.V., Guendel, I., Jaworski, E., Sampey, G., Klase, Z., Chen, H., Zeng, C., Kovalskyy, D., Lepene, B., Patanarut, A., Nekhai, S., Price, D.H. and Kashanchi, F. (2013) Effect of mimetic Cdk9 inhibitors on HIV-1 activated transcription. J Mol Biol, 425(4):812-29.

Zhou, Q., Li, T. and Price, D.H. (2012) RNA Polymerase II Elongation Control. Annual Review of Biochemistry, 81:119-43.

Kulak, M.V., Cyr, A.R., Woodfield, G.W., Bogachek, M., Spanheimer, P.M., Li, T., Price, D.H., Domann, F.E. and Weigel, R.J. (2012) Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene, doi: 10.1038/onc.2012.400 [Epub ahead of print].

Fujinaga, K., Barboric, M., Li, Q., Luo, Z., Price, D.H. and Peterlin, B.M. (2012) PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nuc. Acids Res. (Epub PMID: 22821562).

Li, T. and Price, D.H. (2012) Gdown1- mkaing a link between Mediator and RNA polymerase II elongation control. Transcription, 3:1-3.

Nguyen, D., Krueger, B.J., Sedore, S.C., Brogie, J.E., Rogers, J.T., Rajendra, T.K., Saunders, A., Matera, A.G., Lis, J.T., Uguen, P. and Price, D.H. (2012) The Drosophila 7SK snRNP and the essential role of dHEXIM in development. Nuc. Acids Res. (Epub PMID: 22379134).

Cheng, B., Li, T., Rahl, P.B., Adamson, T.E., Loudas, N.B., Gou, J., Varzavand, K., Cooper, J.J., Hu, X., Gnatt, A., Young, R.A. and Price, D.H. (2012) Functional association of Gdown1 with RNA polymerase II poised on human genes. Molecular Cell, 45:38-50.

Peterlin, B.M., Brogie, J.E. and Price, D.H. (2012) 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. WIREs RNA 2012, 3:92-103.

Nilson, K.A. and Price, D.H. (2011) The role of RNA polymerase II elongation control in HIV-1 gene expression, replication, and latency. Genetics Research International Volume 2011, Article ID 726901.

Cojocaru, M., Bouchard, A. Cloutier, P. Cooper, J.J., Varzavand, K. Price D.H. Coulombe B. (2011) Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor b.  J. Biol. Chem. 286:5012-22.

Bartkowiak, B., Liu, P., Phatnani, H.P., Fuda, N.J., Cooper, J.J., Price, D.H., Adelman, K, Lis, J.T., and Greenleaf, A.L. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & Development 24:2303-16.

Price, D.H. (2010) Regulation of RNA polymerase II elongation by c-Myc. Cell. Apr 30;141(3):399-400.

Krueger, B.J., Varzavand, K., Cooper, J.J., and Price, D.H. (2010) The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators incudes a conformational change in 7SK. PLoS ONE 23:e12335.

Tahirov, T.H., Babayeva, N.D., Varzavand, K., Cooper, J.J., Sedore, S.C., and Price, D.H. (2010) Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature, 465:747-751

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